Liga ASOBAL 2005–06 season was the 16th since its establishment. A total of 16 teams competed this season for the championship.
Competition format
The competition was played in a round-robin format, through 30 rounds. The team with most points earned wins the championship. The last two teams were relegated.
Overall standing
Conclusions
- FC Barcelona-Cifec -- EHF Champions League and Liga ASOBAL Champion
- BM Ciudad Real -- EHF Champions League
- Portland San Antonio -- EHF Champions League
- BM Valladolid -- EHF Champions League
- Caja España Ademar León -- EHF Cup Winner's Cup
- CD Bidasoa -- EHF Cup
- CAI BM Aragón -- EHF Cup
- BM Alcobendas—Relegated to División de Honor B
- CB Cangas—Relegated to División de Honor B
Top goal scorers
Top goalkeepers
